What substrates comprise the neurophysiology of human host responses to a particular pathogen?  

In human models we aim to dissect the host response that recursively control neuroinflammation, pain, behavior and cognition.

Our goal is to uncover basic science mechanisms (biology based) using novel tools (Neuro-biosensors compiled with molecular signatures) that may lead to new interventions (Neurotechnologies).

Human Translation Core:  We employ controlled human neuroinflammation and stress challenges while acquiring high precision deep phenotyping (i.e., neurophysiology, proteomic, transcriptomic, metabolomic, sleep physiology, psychiatric and cognitive testing). Challenges can include: intravenous Lipopolysaccharide Injection, vaccine challenge, live virus challenge, sleep deprivaion, cold water exposure, and deep breathing exercises.  Once neuro-immune/neurophysiological response states are established we acquire Functional Magnetic Resonance Imaging (fMRI), Magnetoencephalography (MEG), Magnetoneurography (MNG), Electroencephalography (EEG), Electrogastrography (EGG) and high temporal resolution physiological/autonomic monitoring while also sampling cerebrospinal fluid, peripheral blood and or saliva.  Collectively we aim to identify molecular and neurophysiological bioindicators to refine our understanding of the variability in autonomic nervous system gradients.